Presence of SARS-CoV-2 in semen of men with COVID-19: a systematic review
DOI:
https://doi.org/10.24265/horizmed.2021.v21n4.13Keywords:
Semen, Coronavirus infections, Semen analysisAbstract
The COVID-19 pandemic has caused an unknown impact on the male reproductive health. Therefore, this article aimed to collect evidence to discover if the causative agent of COVID-19 is found in semen. A search was carried out in the PubMed, BVS and Google Scholar databases. Articles with results of semen analyses to determine the presence of SARS-CoV-2 in men diagnosed with COVID-19 were considered. Eleven studies with a total of 296 samples were collected in this review, out of which only 2.70 % showed positive results. In addition, mixed results regarding the morphology of the spermatozoa, as well as patients with azoospermia or oligospermia, were reported. The latter could be a consequence of the high levels of the angiotensin converting enzyme 2 (ACE2) in the testes, making them a target organ for SARS-CoV-2. It is concluded
that, due to the limited number of studies and samples, it is still not possible to answer this study question.
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References
World Health Organization. Novel Coronavirus (2019-nCoV): situation report, 1 [Internet]. WHO; 2020. Disponible en: https://apps.who.int/iris/handle/10665/330760
Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early transmission dynamics in Wuhan, China, of novel Coronavirus-infected pneumonia. N Engl J Med. 2020; 382(13): 1199-207.
Burke RM, Midgley CM, Dratch A, Fenstersheib M, Haupt T, Holshue M, et al. Active monitoring of persons exposed to patients with confirmed COVID-19 - United States, January-February 2020. MMWR Morb Mortal Wkly Rep. 2020; 69(9): 245-6.
Organización Mundial de la Salud. Vías de transmisión del virus de la COVID-19: repercusiones para las recomendaciones relativas a las precauciones en materia de prevención y control de las infecciones [Internet]. OMS; 2020. Disponible en: https://www.who.int/es/news-room/commentaries/detail/modes-of-transmission-of-virus-causing-covid-19-implications-for-ipc-precaution-recommendations
Peng L, Liu J, Xu W, Luo Q, Chen D, Lei Z, et al. SARS-CoV-2 can be detected in urine, blood, anal swabs, and oropharyngeal swabs specimens. J Med Virol. 2020; 92(9): 1676-80.
Wang W, Xu Y, Gao R, Lu R, Han K, Wu G, et al. Detection of SARS-CoV-2 in different types of clinical specimens. JAMA. 2020; 323(18): 1843-4.
Yan Y, Chang L, Wang L. Laboratory testing of SARS-CoV, MERS-CoV, and SARS-CoV-2 (2019-nCoV): Current status, challenges, and countermeasures. Rev Med Virol. 2020; 30(3): e2106.
Xu J, Qi L, Chi X, Yang J, Wei X, Gong E, et al. Orchitis: a complication of severe acute respiratory syndrome (SARS). Biol Reprod. 2006; 74(2): 410-6.
Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020; 382(18): 1708-20.
Mangia C, Russo A, Civitelli S, Gianicolo EAL. Sex/gender differences in COVID-19 lethality: what the data say, and do not say. Epidemiol Prev. 2020; 44(5-6 Suppl 2): 400-6.
Bwire GM. Coronavirus: Why men are more vulnerable to Covid-19 than women?. SN Compr Clin Med. 2020; 1-3.
Salam AP, Horby PW. The breadth of viruses in human semen. Emerg Infect Dis. 2017; 23(11): 1922-4.
Mansuy JM, Suberbielle E, Chapuy-Regaud S, Mengelle C, Bujan L, Marchou B, et al. Zika virus in semen and spermatozoa. Lancet Infect Dis. 2016; 16(10): 1106-7.
Brainard J, Pond K, Hooper L, Edmunds K, Hunter P. Presence and persistence of Ebola or Marburg virus in patients and survivors: A rapid systematic review. PLoS Negl Trop Dis. 2016; 10(2): e0004475.
Zhao S, Zhu W, Xue S, Han D. Testicular defense systems: immune privilege and innate immunity. Cell Mol Immunol. 2014; 11(5): 428-37.
Munn Z, Peters MDJ, Stern C, Tufanaru C, McArthur A, Aromataris E. Systematic review or scoping review? Guidance for authors when choosing between a systematic or scoping review approach. BMC Med Res Methodol. 2018; 18(1): 143.
Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009; 6(7): e1000097.
Kayaaslan B, Korukluoglu G, Hasanoglu I, Kalem AK, Eser F, Akinci E, et al. Investigation of SARS-CoV-2 in semen of patients in the acute stage of COVID-19 infection. Urol Int. 2020; 104(9–10): 678-83.
Pan F, Xiao X, Guo J, Song Y, Li H, Patel DP, et al. No evidence of severe acute respiratory syndrome-coronavirus 2 in semen of males recovering from coronavirus disease 2019. Fertil Steril. 2020; 113(6): 1135-9.
Holtmann N, Edimiris P, Andree M, Doehmen C, Baston-Buest D, Adams O, et al. Assessment of SARS-CoV-2 in human semen-a cohort study. Fertil Steril. 2020; 114(2): 233-8.
Li D, Jin M, Bao P, Zhao W, Zhang S. Clinical characteristics and results of semen tests among men with Coronavirus disease 2019. JAMA Netw Open. 2020; 3(5): e208292.
Paoli D, Pallotti F, Colangelo S, Basilico F, Mazzuti L, Turriziani O, et al. Study of SARS-CoV-2 in semen and urine samples of a volunteer with positive naso-pharyngeal swab. J Endocrinol Invest. 2020; 43(12): 1819-22.
Temiz MZ, Dincer MM, Hacibey I, Yazar RO, Celik C, Kucuk SH, et al. Investigation of SARS-CoV-2 in semen samples and the effects of COVID-19 on male sexual health by using semen analysis and serum male hormone profile: A cross-sectional, pilot study. Andrologia. 2021; 53(2): e13912.
Guo L, Zhao S, Li W, Wang Y, Li L, Jiang S, et al. Absence of SARS-CoV-2 in semen of a COVID-19 patient cohort. Andrology. 2021; 9(1): 42-7.
Burke CA, Skytte AB, Kasiri S, Howell D, Patel ZP, Trolice MP, et al. A cohort study of men infected with COVID-19 for presence of SARS-CoV-2 virus in their semen. J Assist Reprod Genet. 2021; 38(4): 785-9.
Machado B, Barra GB, Scherzer N, Massey J, Luz HDS, Jacomo RH, et al. Presence of SARS-CoV-2 RNA in semen-cohort study in the United States COVID-19 positive patients. Infect Dis Rep. 2021; 13(1): 96-101.
Gacci M, Coppi M, Baldi E, Sebastianelli A, Zaccaro C, Morselli S, et al. Semen impairment and occurrence of SARS-CoV-2 virus in semen after recovery from COVID-19. Hum Reprod. 2021; 36(6): 1520-9.
Ruan Y, Hu B, Liu Z, Liu K, Jiang H, Li H, et al. No detection of SARS-CoV-2 from urine, expressed prostatic secretions, and semen in 74 recovered COVID-19 male patients: A perspective and urogenital evaluation. Andrology. 2021; 9(1): 99-106.
Gonzalez DC, Khodamoradi K, Pai R, Guarch K, Connelly ZM, Ibrahim E, et al. A systematic review on the investigation of SARS-CoV-2 in semen. Res Rep Urol. 2020; 12: 615-21.
Massarotti C, Garolla A, Maccarini E, Scaruffi P, Stigliani S, Anserini P, et al. SARS-CoV-2 in the semen: Where does it come from?. Andrology. 2021; 9(1): 39-41.
Lukassen S, Chua RL, Trefzer T, Kahn NC, Schneider MA, Muley T, et al. SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells. EMBO J. 2020; 39(10): e105114.
Cheng H, Wang Y, Wang GQ. Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19. J Med Virol. 2020; 92(7): 726-30.
Fu J, Zhou B, Zhang L, Balaji KS, Wei C, Liu X, et al. Expressions and significances of the angiotensin-converting enzyme 2 gene, the receptor of SARS-CoV-2 for COVID-19. Mol Biol Rep. 2020; 1-10.
Liu X, Chen Y, Tang W, Zhang L, Chen W, Yan Z, et al. Single-cell transcriptome analysis of the novel coronavirus (SARS-CoV-2) associated gene ACE2 expression in normal and non-obstructive azoospermia (NOA) human male testes. Sci China Life Sci. 2020; 63(7): 1006-15.
Shen Q, Xiao X, Aierken A, Yue W, Wu X, Liao M, et al. The ACE2 expression in Sertoli cells and germ cells may cause male reproductive disorder after SARS-CoV-2 infection. J Cell Mol Med. 2020; 24(16): 9472-7.
Moghimi N, Farsani BE, Ghadipasha M, Mahmoudiasl GR, Piryaei A, Aliaghaei A, et al. COVID-19 disrupts spermatogenesis through the oxidative stress pathway following induction of apoptosis. Apoptosis. 2021; 1-16.
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