Programmed death-ligand 1 (PD-L1) expression in Hodgkin’s lymphoma among Peruvian patients

Authors

  • María del Rosario Villa Robles Instituto Nacional de Enfermedades Neoplásicas (INEN). Lima, Perú. Laboratorio de Inmunohistoquímica del INEN. Lima, Perú. Bióloga(o). Coordinadora del laboratorio de inmunohistoquímica del INEN. https://orcid.org/0000-0001-8780-3700
  • Sandro Casavilca Zambrano Instituto Nacional de Enfermedades Neoplásicas (INEN). Lima, Perú. Equipo funcional de patología quirúrgica del INEN. Lima, Perú. Médico cirujano, especialista en anatomía patológica. Doctor en neurociencias. Director del Departamento de Patología del INEN. https://orcid.org/0000-0001-8406-739X
  • Ruddy Liendo Picoaga Instituto Nacional de Enfermedades Neoplásicas (INEN). Lima, Perú. Banco de tejidos tumorales del INEN. Lima, Perú. Bióloga(o). Magister en biología molecular. https://orcid.org/0000-0003-3570-8802
  • Ana Cecilia Barrionuevo Ponte Universidad Peruana de Ciencias Aplicadas (UPC). Lima, Perú. Interna de medicina. https://orcid.org/0000-0001-7425-0377
  • Ana Sofía Barrionuevo Ponte Universidad Peruana de Ciencias Aplicadas (UPC). Lima, Perú. Interna de medicina. https://orcid.org/0000-0002-9227-0125
  • Carlos Barrionuevo Cornejo Instituto Nacional de Enfermedades Neoplásicas (INEN). Lima, Perú. Equipo funcional de patología quirúrgica del INEN. Lima, Perú. Universidad Nacional Mayor de San Marcos (UNMSM). Lima, Perú. Médico cirujano, especialista en anatomía patológica. Doctor en medicina. Jefe del equipo funcional de patología quirúrgica del INEN. https://orcid.org/0000-0003-2474-914X

DOI:

https://doi.org/10.24265/horizmed.2022.v22n3.02

Keywords:

Hodgkin Disease, Proteins , Neoplasms, Immunohistochemistry

Abstract

Objective: Various studies on Hodgkin’s lymphoma (HL) have determined programmed death-ligand 1 (PD-L1) expression in Hodgkin and Reed-Sternberg (HRS) cells, with variable results. This protein has gained relevance for its role in the
immune response in malignant neoplasms. This work aimed to determine PD-L1 immunohistochemical expression in HRS cells and its relationship with age, sex, clinical stage and overall survival (OS) in a cohort of Peruvian patients. Materials and methods: Twenty-five (25) biopsies from patients diagnosed with HL were assessed, which allowed determining PD-L1 immunohistochemical expression in HRS cells in relation to OS and clinical data of the patients. Results: All cases showed PD-L1 expression in more than 1 % of tumor cells. There was no statistically significant difference in OS when two groups were compared in terms of PD-L1 expression with a cut-off point of 50 %, clinical stage (CS), age and sex. Conclusions: High PD-L1 expression was found in pre-treatment HL tumors. No association was found between PD-L1 expression, OS, age, sex or CS. Further studies with a larger number of patients are necessary to reassess the prognostic
impact of the expression of this protein in HL.

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Published

2022-09-27

How to Cite

1.
Villa Robles M del R, Casavilca Zambrano S, Liendo Picoaga R, Barrionuevo Ponte AC, Barrionuevo Ponte AS, Barrionuevo Cornejo C. Programmed death-ligand 1 (PD-L1) expression in Hodgkin’s lymphoma among Peruvian patients. Horiz Med [Internet]. 2022Sep.27 [cited 2025May2];22(3):e1927. Available from: https://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/1927

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