Factors associated with adherence to drug therapy among patients with diabetes without hypertension
DOI:
https://doi.org/10.24265/horizmed.2023.v23n4.01Keywords:
medication adherence, diabetes mellitus type 2, essential hypertensionAbstract
Objective: To identify the factors associated with adherence to drug therapy among patients with type 2 diabetes mellitus without hypertension. Materials and methods: A cross-sectional, analytical study conducted with patients with type 2 diabetes mellitus
without hypertension, divided into an adherent group (n = 145) and a non-adherent group (n = 49), determined by the 4-item Morisky Medication Adherence Scale (MMAS-4). The associated factors were sex, cohabitation, schooling, occupation, age in 10-year groups and diabetes progression time grouped in less than 1 year, from 1 to 5 years, from
6 to 10 years and more than 10 years. The statistical analysis plan included the chi-square test. Results: The factors associated with adherence to drug therapy were identified as sex (p = 0.045), cohabitation (p = 0.045), age (p = 0.001) and disease progression time (p = 0.001). Schooling was not identified as a factor associated with adherence
to drug therapy among patients with type 2 diabetes mellitus (p = 0.289). The older the patient with diabetes, the lower the adherence to drug therapy; the cut-off point was 60 years of age, after which the percentage in the non-adherent group was higher than in the adherent group (p = 0.001). The longer the diabetes progression time, the lower the probability of adherence; in the non-adherent group the percentage of patients with more than 10 years of disease progression was 67.3 % and in the adherent group the percentage was 33.8 % (p = 0.001). Conclusions: The factors associated with adherence to drug therapy among patients with type 2 diabetes mellitus without hypertension were identified.
Downloads
References
Ramirez MC, Anlehu A, Rodriguez A. Factores que influyen en el comportamiento de adherencia del paciente con diabetes mellitus tipo 2. Horiz Sanitario. 2019;18(3):383-92.
Asociacion Latinoamericana de Diabetes. Guias ALAD sobre el diagnostico, control y tratamiento de la diabetes Mellitus tipo 2 con medicina basada en evidencia [Internet]. Permanyer Mexico. Mexico: Comite Editorial de la Revista ALAD; 2019 [citado 12 de julio de 2023]. 1-119 p. Disponible en: https://www.revistaalad.com/guias/5600AX191_guias_alad_2019.pdf
Reed J, Bain S, Kanamarlapudi V. A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives. Diabetes, Metab Syndr Obes Targets Ther. 2021;14:3567-602.
American Diabetes Association. 9. Pharmacologic approaches to glycemic treatment: Standards of medical care in diabetes-2020. Diabetes Care. 2020;43(Suppl 1):S98-110.
Pascacio-Vera GD, Ascencio-Zarazua GE, Cruz-Leon A, Guzman-Priego CG. Adherencia al tratamiento y conocimiento de la enfermedad en pacientes con diabetes mellitus tipo 2. Salud Tab. 2016;22(1-2):2331.
Ivers NM, Jiang M, Alloo J, Singer A, Ngui D, Casey CG, et al. Diabetes Canada 2018 clinical practice guidelines. Can Fam Physician. 2019;65(1):14-24.
Instituto Mexicano del Seguro Social. Diagnostico y tratamiento de la enfermedad hemolitica por isoinmunizacion a RH en el recien nacido [Internet]. Mexico; 2018. 1-60 p. Disponible en: https://www.imss.gob.mx/sites/all/statics/guiasclinicas/373GER.pdf
Munoz D, Olarte MT, Salamanca E. Grado de adherencia terapeutica en pacientes en unidades de cuidados intensivos. Enfermeria Glob. 2021;20(1):1-22.
Orozco-Beltran D, Mata-Cases M, Artola S, Conthe P, Mediavilla J, Miranda C. Abordaje de la adherencia en diabetes mellitus tipo 2: situacion actual y propuesta de posibles soluciones. Atencion Primaria, 2016;48(6):406-20.
Angelucci-Bastidas L, Rondon-Bernard JE. Adherencia al tratamiento en diabetes tipo 2: Un modelo de regresion logistica. Caracas 20172018. Med UIS. 2021;34(2):29-39.
Ramos Y, Morejon R, Gomez M, Suarez ME, Rangel C, Cabrera Y. Adherencia terapeutica en pacientes con diabetes mellitus tipo 2. Finlay. 2017;7(2):89-98.
Barroso ML, Mora A, Sierra E. Adherencia terapeutica en los pacientes sometidos a intervencionismo coronario percutaneo primario. Enferm Cardiol. 2021;(82):46-51.
Grupo de trabajo uso adecuado del medicamento en diabetes. Recomendaciones para la seleccion del tratamiento farmacologico en diabetes mellitus tipo 2 [Internet]. Andalucia: Escuela Andaluza de Salud Publica; 2020 p. 1-16. Disponible en: https://www.semergenandalucia.org/docs/noticias/mellitosTipo2.pdf
Reyes-Flores E, Trejo-Alvarez R, Arguijo-Abrego S, Jimenez-Gomez A, Castillo-Castro A, Hernandez-Silva A, et al. Adherencia terapeutica: conceptos, determinantes y nuevas estrategias. Rev Med Hondur. 2016;84(3/4):125-32.
Zenteno-Lopez MA, Tzontehua-Tzontehua I, Gil-Londono E, Contreras-Arroyo S, Galicia-Aguilar R. Continuidad de cuidados para la adherencia terapeutica en la persona con diabetes tipo 2. Enferm Univ. 2016;13(2):130-7.
Zhou X, Siegel KR, Ng BP, Jawanda S, Proia KK, Zhang X, et al. Costeffectiveness of diabetes prevention interventions targeting highrisk individuals and whole populations: A systematic review. Diabetes Care. 2020;43(7):1593-616.
Ipingbemi AE, Erhun WO, Adisa R. Pharmacist-led intervention in treatment non-adherence and associated direct costs of management among ambulatory patients with type 2 diabetes in southwestern Nigeria. BMC Health Serv Res. 2021;21(1):1000.
Martinez-Dominguez IG, Martinez-Sanchez ML, Lopera-Valle JS, Vargas-Grisales N. La importancia de la adherencia terapeutica. Rev Venez Endocrinol Metab. 2016;14(2):107-16.
Rincon-Romero MK, Torres-Contreras C, Corredor-Pardo KA. Adherencia terapeutica en personas con diabetes mellitus tipo 2. Rev Cienc Cuid. 2017;14(1):40-59.
Organizacion Mundial de la Salud. Adherencia a los tratamientos a largo plazo: Pruebas para la accion [Internet]. Washington, D.C.: OMS; 2004. 1-198 p. Disponible en: https://iris.paho.org/bitstream/handle/10665.2/41182/adherencia-largo-plazo.pdf?sequence=1&isAllowed=y
Basto-Abreu A, Barrientos-Gutierrez T, Rojas-Martinez R, AguilarSalinas CA, Lopez-Olmedo N, De la Cruz-Gongora V, et al. Prevalencia de diabetes y descontrol glucemico en Mexico: resultados de la Ensanut 2016. Salud Publica Mex. 2020;62(1):50-9.
Rojas-Martinez R, Basto-Abreu A, Aguilar-Salinas CA, Zarate-Rojas E, Villalpando S, Barrientos-Gutierrez T. Prevalencia de diabetes por diagnostico medico previo en Mexico. Salud Publica Mex. 2018;60(3):224-32.
Sociedad Espanola de Farmacia Hospitalaria. Lo que debes saber sobre la adherencia al tratamiento [Internet]. Espana; 2017. 1-194 p. Disponible en: https://www.sefh.es/bibliotecavirtual/Adherencia2017/libro_ADHERENCIA.pdf
Farias-Vilchez BA, Bardales D. Conocimientos sobre diabetes mellitus tipo 2 y adherencia al tratamiento en pacientes del hospital Reategui, Piura, Peru. Acta Med Peru. 2021;38(1):34-41.
Pfizer. La adherencia al tratamiento: cumplimiento y constancia para mejorar la calidad de vida [Internet]. Madrid: Pfizer; p. 1-11. Report No.: 3. Disponible en: http://envejecimiento.csic.es/documentos/documentos/pfizer-adherencia-01.pdf
Mora GR, Verdecia K, Rodriguez TM, Del Pino BN, Guerra C. Therapeutic adherence in patient with noncommunicable chronic diseases. RCMGI. 2017;33(3):270-80.
Dang BN, Westbrook RA, Njue SM, Giordano TP. Building trust and rapport early in the new doctor-patient relationship: a longitudinal qualitative study. BMC Medical Education. 2017;17(1):32.
Zaldivar Y, Fuentes HC, Garcia ME. Contradicciones sociales en la formacion de valores desde la relacion medico-paciente-familia en profesionales de las ciencias medicas. MEDISAN. 2021;25(1):238-50.
Limaylla ML, Ramos NJ. Metodos indirectos de valoracion del cumplimiento terapeutico. Cien Investig. 2016;19(2):95-101.
Lopez-Romero LA, Romero-Guevara SL, Parra DI, Rojas-Sanchez LZ. Adherencia al tratamiento: concepto y medicion. Hacia Promoc Salud. 2016;21(1):117-37.
Pages-Puigdemont N, Valverde-Merino MI. Metodos para medir la adherencia terapeutica. Ars Pharm.2018;59(3):163-72.
Rodriguez MA, Garcia-Jimenez E, Amariles P, Rodriguez A, Faus JM. Revision de tests de medicion del cumplimiento terapeutico utilizados en la practica clinica. Aten Primaria. 2008;40(8):413-8.
Fundacion redGDPS. Adherencia terapeutica en personas con diabetes. En: Guia de diabetes tipo 2 para clinicos: recomendaciones de la redGDPS [Internet]. 1.ï¿1/2 ed. Espana: redGDPS; 2018. p. 220-5. Disponible en: https://www.redgdps.org/gestor/upload/colecciones/220_guiadm2_capGuia%20DM2_web.pdf
American Diabetes Association. Standards of Medical Care in Diabetes-2022 Abridged for Primary Care Providers. Clinical Diabetes. 2022;40(1):10-38.
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Hasalia Díaz Santiago, Daniel Marcial Cruz, Liliana Galicia Rodríguez, Enrique Villarreal Ríos, Concepción Julián López, Jesús Elizarrarás Rivas
This work is licensed under a Creative Commons Attribution 4.0 International License.
Horizonte Médico (Lima) (Horiz. Med.) journal’s research outputs are published free of charge and are freely available to download under the open access model, aimed at disseminating works and experiences developed in biomedical and public health areas, both nationally and internationally, and promoting research in the different fields of human medicine. All manuscripts accepted and published in the journal are distributed free of charge under the terms of a Creative Commons license – Attribution 4.0 International (CC BY 4.0).
