Fahr’s disease in an older adult: a geriatric view

Authors

DOI:

https://doi.org/10.24265/horizmed.2025.v25n1.14

Keywords:

Delirium, Calcinoses, Frailty, Aged

Abstract

Fahr’s disease is an unusual condition, characterized by bilateral and symmetrical intracranial
calcifications. We present the case of a 75-year-old man, who was admitted to the emergency
room due to a biliary obstruction following a periampullary neoplasm. During his stay, the patient
fell after an episode of psychomotor agitation without apparent cause; therefore, it led to a
computed tomography (CT) scan of the brain, which revealed bilateral calcified lesions in the basal
nuclei and globus pallidus. The disease was managed exclusively, but there were shortcomings
in the integrated approach to the older adult. Subsequently, during the comprehensive geriatric
assessment, it was detected that the was a frail elderly patient, with acquired deconditioning,
malnutrition, social vulnerability, and caregiver overload.
This suggests that the approach to frail older adult patients in hospitalization areas is alarmingly
insufficient and is reflected in a critical gap in the training and development of specialized
geriatric practices. The lack of adequate knowledge about the complexities and specific needs
of this vulnerable population results in suboptimal care, prolonged hospital stays, and an
increase in complication and readmission rates, not only due to the disease but also because of the
overlooked social context. This deficiency highlights the urgent need to prioritize the comprehensive
management of older adults across all specialties and geriatrics, promoting more robust training for
healthcare professionals and the development of specific protocols that ensure integrated, safe, and
dignified care.

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References

Mila J. Evers, Dominik Gross, Stephanie Kaiser. Just “one of so

many”? The pathologist Theodor Fahr (1877–1945) and his ambivalent

relationship to National Socialism. Pathol Res Pract [Internet].

;224(153488):153488.

Yamada N, Hayashi T. [Asymptomatic familial basal ganglia

calcification with autosomal dominant inheritance: a family report].

No To Hattatsu [Internet]. 2000 Nov;32(6):515-9.

Saleem S, Aslam HM, Anwar M, Anwar S, Saleem M, Saleem A, Rehmani

MA. Fahr’s syndrome: literature review of current evidence. Orphanet

J Rare Dis [Internet]. 2013;8:156.

Mufaddel AA, Al-Hassani GA. Familial idiopathic basal ganglia

calcification (Fahr`s disease). Neurosciences (Riyadh) [Internet].

;19(3):171-7.

Perugula ML, Lippmann S. Fahr’s Disease or Fahr’s Syndrome? Innov Clin

Neurosci [Internet]. 2016;13(7-8):45-6.

Mesía-Ángeles, D., Anticona-Sayán, M. Síndrome de Fahr y síndrome

poliglandular tipo 4 en un paciente con secreción inadecuada de

hormona antidiurética. Spmi [Internet]. 2022;35(1):23-26.

Lira D, Custodio N, Montesinos R, Torres H. Calcificaciones cerebrales

extensas y corea, en hipoparatiroidismo probablemente posquirúrgico.

An Fac Med [Internet]. 2009;70(2):119-22.

Dávila-Hernández C, Bendezú-Ramos G, Torres-Luján M,

Cárdenas-Trejo J, Picoy-Romero D. Calcificaciones cerebrales:

enfermedad o síndrome de Fahr. Spmi [Internet]. 2021;34(1):12-14.

Pamo-Reyna, OG., Cumpa-Quiroz, R., Rosales-Mendoza, K.,

Cabellos-Gavidia, D. Enfermedad de Fahr. Spmi [Internet].

;26(1):48.

Pinzon Tovar A, Mendez H, Jimenez Salazar S, Oviedo Cali M,

Buitrago-Toro K. Clinical Spectrum of FAHR Syndrome: Report of two

cases. Rev ACE [Internet]. 2022;9(3):e752.

Amisha F, Munakomi S. Fahr Syndrome [Internet]. Treasure Island

(FL): StatPearls Publishing; 2024. Disponible en: https://www.ncbi.

nlm.nih.gov/books/NBK560857/

Savino E, Soavi C, Capatti E, Borrelli M, Vigna GB, Passaro A, Zuliani

G. Bilateral strio-pallido-dentate calcinosis (Fahr’s disease): report

of seven cases and revision of literature. BMC Neurol [Internet].

;16(1):165.

Bowirrat A, Yassin M, Artoul F, Artul S. Fahr’s disease: bilateral

symmetrical striopallidodentate calcification in two brothers with two

distinct presentations. BMJ Case Rep [Internet]. 2013:bcr2013200462.

Pourshahid S, Salloum MN, Elfishawi M, Barakat M, Basith M. Fahr’s

Disease: A Differential to Be Considered for Various Neuropsychiatric

Presentations. Cureus [Internet]. 2018;10(3):e2304.

Chaudhari D, Pushpendra NR. Fahr’s disease: A rare neurological

disease. Apollo Medicine [Internet]. 2015;12(2):148-151.

Sourav S, Sneha AS, Edzel L. Fahr’s disease with an atypical onset of

epileptic seizure. Radiol Case Rep [Internet]. 2022;17(9):3139-3141.

Manea MM, Sirbu A, Dragos D, Dobri AM, Sirbu AG, Tuta S. Epilectic

seizures as the First Manifestation of Fahr´s Syndrome. Acta Endo

(Buc) [Internet]. 2020;16(3):370-4.

Wong YG, Hang JA, Francis-Coad J, Hill AM. Using comprehensive

geriatric assessment for older adults undertaking a facility-based

transition care program to evaluate functional outcomes: a feasibility

study. BMC Geriatr [Internet]. 2022;22(1):1-12.

Rezaei-Shahsavarloo Z, Atashzadeh-Shoorideh F, Gobbens RJJ,

Abbas E, Ghaedamini-Harouni G. The impact of interventions on

management of frailty in hospitalized frail older adults: a systematic

review and meta-analysis. BMC Geriatr [Internet]. 2020;20(1):1-17.

Mah JC, Godin J, Stevens SJ, Keefe JM, Rockwood K, Andrew MK.

Social Vulnerability and Frailty in Hospitalized Older Adults. Can

Geriatr J [Internet]. 2023;26(3):390-9.

Heydari A, Sharifi M, Moghaddam AB. Challenges and Barriers to

Providing Care to Older Adult Patients in the Intensive Care Unit:

A Qualitative Research. Open Access Maced J Med Sci [Internet].

;7(21):3682-90.

Published

2025-03-12

How to Cite

1.
Damián-Mucha M, Takami-Angeles G, Arroyo-Zevallos C, Gamarra-Samaniego M, Torres-Salinas C. Fahr’s disease in an older adult: a geriatric view. Horiz Med [Internet]. 2025Mar.12 [cited 2025May1];25(1):e2855. Available from: https://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/2855

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Section

Case report