Influence of high altitude on C-reactive protein levels in adults with abdominal visceral adiposity

Authors

DOI:

https://doi.org/10.24265/horizmed.2018.v18n1.05

Keywords:

Protein C, Adiposity, Altitude

Abstract

Objective: To evaluate the influence of high altitude on C-reactive protein (CRP) levels in adults with abdominal visceral adiposity. Materials and methods: A quantitative study with quasi-experimental design, which included twenty-four (24) male medical students from the National University of Trujillo, selected by non-probability convenience sampling and study subject, evaluated at 0 and 4,386 m.a.s.l., and classified according to their degree of abdominal visceral adiposity: normal (G1) and high (G2). Results: The CRP level of G1 in relation to G2 showed no significant difference. Regarding CRP levels, Wilcoxon rank-sum (non-parametric) test was used for G2 and Student´s t-test was used for G1, with significance being shown in both cases. Conclusions: Variations on CRP levels in high altitude compared to sea level in both groups were significant.

Downloads

Download data is not yet available.

References

Michiels C. Physiological and Pathological Responses to Hypoxia. AJP. 2004; 164(6): 1875-82. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/15161623

Acevedo M, Arnáiz P, Barja S, Bambs C, Berrios X, Guzmán B, et al. Proteína C reactiva y su relación con adiposidad, factores de riesgo cardiovascular y aterosclerosis subclínica en niños sanos. Rev Esp Cardiol. 2007; 60(10): >1051-8. Disponible en: http://www.revespcardiol.org/es/proteina-c-reactiva-su-relacion/articulo/13111237/

Devaraj S, Singh U, Jialal I. Evolución del papel de la proteína C reactiva en aterotrombosis. Química Clínica. 2009; 55(2): 229-238.

Manzur F, Alvear C, Alayón A. Adipocitos, obesidad visceral, inflamación y enfermedad cardiovascular. Rev Colom Cardiol. 2010; 17(5): 210. Disponible en: https://www.sciencedirect.com/science/article/pii/S0120563310702436

Irkulla S, Ujam B, Gaze D, Kumar D, Mendall M. Abdominal adiposity is the main determinant of the C-reactive response to injury in subjects undergoing inguinal hernia repair. J Inflamm. 2013; 10(5):1-9. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579693/

Tsuriya D, Morita H, Morioka T, Takahashi N, Ito T, Oki Y, et al. Significant correlation between visceral adiposity and high-sensitivity C-reactive protein (hs-CRP) in Japanese subjects. Intern Med. 2011; 50(22):2767-73. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/22082888

Saijo Y, Kiyota N, Kawasaki Y, Miyazaki Y, Kashimura J, Fukuda M, et al. Relationship between C-reactive protein and visceral adipose tissue in healthy Japanese subjects. Diabetes Obes Metab. 2004; 6(4):249-58. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/15171748

Forouzan Z, Leila P, Soheila Y, Fatemeh A. Relationships between human serum C reactive protein, glucose concentration and insulin sensitivity in obese or overweight women. J. Bio. & Env. Sci. 2014; 4(2): 256-61. Disponible en: http://www.innspub.net/wp-content/uploads/2014/03/JBES-Vol4No1-p256-261.pdf

Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev. 2004; 84(1): 277-359. Disponible en: http://www.physiology.org/doi/abs/10.1152/physrev.00015.2003

Kim K, Valentine J, Shin Y, Gong K. Associations of visceral adiposity and exercise participation with C-reactive protein, insulin resistance, and endothelial dysfunction in Korean healthy adults. Metabolism. 2008; 57(9):1181-9. Disponible en: http://www.sciencedirect.com/science/article/pii/S0026049508001406

Tsuriya D, Morita H, Morioka T, Takahashi N, Ito T, Oki Y, et al. Significant correlation between visceral adiposity and high-sensitivity C-reactive protein (hs-CRP) in Japanese subjects. Intern Med. 2011; 50(22):2767-73. Disponible en: https://www.jstage.jst.go.jp/article/internalmedicine/50/22/50_22_2767/_article/-char/ja/

Saijo Y, Kiyota N, Kawasaki Y, Miyazaki Y, Kashimura J, Fukuda M, et al. Relationship between C-reactive protein and visceral adipose tissue in healthy Japanese subjects. Diabetes Obes Metab. 2004; 6(4):249-58. Disponible en: http://onlinelibrary.wiley.com/doi/10.1111/j.1462-8902.2003.0342.x/full

Bouloukaki I, Mermigkis Ch, Kallergis E, Moniaki V, Mauroudi E, Schiza S. Obstructive sleep apnea syndrome and cardiovascular disease: The influence of C-reactive protein. World J Exp Med. 2015; 5(2): 77-83. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436942/

Hagobian T, Jacobs K, Subudhi A, Fattor J, Rock P, Muza S, et al. Cytokine response at high altitude: effects of exercise and antioxidants at 4300 m. Med Sci Sports Exerc. 2006; 38(2):276–85. Disponible en: http://digitalcommons.calpoly.edu/kine_fac/36/

Hartmann G, Tschöp M, Fischer R, Bidlingmaier C, Riepl R, Tschöp K, et al. High altitude increases circulating Interleukin-6, Interleukin-1 receptor antagonist and C-reactive protein. Cytokine, 2000; 12(3):246–52. Disponible en: http://www.sciencedirect.com/science/article/pii/S1043466699905331

Tomita H, Takamuro M, Soda W, Hatakeyama K, Tsutsumi H. Increased serum high-sensitivity C-reactive protein is related to hypoxia and brain natriuretic peptide in congenital heart disease. Pediatr Int. 2008; 50(4):436-40. Disponible en: http://onlinelibrary.wiley.com/doi/10.1111/j.1442-200X.2008.02581.x/full

Acosta E. Obesidad, tejido adiposo y resistencia a la insulina. Acta Bioquím Clín Latinoam. 2012; 46 (2): 183-94. Disponible en: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572012000200003

Published

2018-03-31

How to Cite

1.
Arteaga-Temoche L, Ayala-Jara C, Castillo Saavedra E, Seclén-Ayala L, Merino Ramírez J, Simón Cruz D, Trujillo Gallardo A, Shimizu Varas R, Zúñiga Luna J, Vallejo Zárate G, Zambrano Quispe J, Julca Carranza J, Samamé Minchón F, Mattos Campos N, Aldave Lázaro K, Charcape Aliaga H, Meléndez Vargas A. Influence of high altitude on C-reactive protein levels in adults with abdominal visceral adiposity. Horiz Med [Internet]. 2018Mar.31 [cited 2025Jun.20];18(1):29-34. Available from: https://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/704

Issue

Section

Original article