Adult T-cell leukemia/lymphoma and systemic cryptococcosis: Report of two cases in a Peruvian hospital
DOI:
https://doi.org/10.24265/horizmed.2019.v19n1.14Keywords:
Adult T-cell leukemia-lymphoma, Opportunistic infections, CryptococcosisAbstract
Adult T-cell leukemia/lymphoma (ATLL) is a lymphoid neoplasm caused by the human T-cell lymphotropic virus type 1 (HTLV-1), an endemic retrovirus in our country. It has a heterogeneous presentation, with sub types of poor prognosis, and opportunistic infections that worsen the prognosis. We present two cases with aggressive varieties of the disease (acute and lymphomatous) complicated by systemic cryptococcosis. It is necessary to conduct a complete diagnostic approach and continuous monitoring of opportunistic agents in patients with ATL adapted to our epidemiological context.
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Proietti FA, Carneiro-Proietti AB, Catalan-Soares BC, Murphy EL. Global epidemiology of HTLV-I infection and associated diseases. Oncogene. 2005; 24(39): 6058–68.
Utsunomiya A, Choi I, Chihara D, Seto M. Recent advances in the treatment of adult T-cell leukemia-lymphomas. Cancer Sci. 2015; 106: 344-351.
Chihara D, Ito H, Matsuda T, Katanoda K, Shibata A, Taniguchi S et al. Association between decreasing trend in the mortality of adult T-cell leukemia ⁄ lymphoma and allogeneic hematopoietic stem cell transplants in Japan: analysis of Japanese vital statistics and Japan Society for Hematopoietic Cell Transplantation (JSHCT). Blood Cancer J. 2013; 3(11): e159.
Tsukasaki K, Tobinai K. Human T-cell lymphotropic virus type I-associated adult T-cell leukemia-lymphoma: new directions in clinical research. Clin Cancer Res. 2014;20(20):5217-25.
Shimoyama M. Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984–87). Br J Haematol 1991; 79: 428–37.
Bazarbachi A, Suarez F, Fields P, Hermine O. How I treat adult T-cell leukemia/lymphoma. Blood. 2011; 118 (7): 1736-45.
Katsuya H, Ishitsuka K. Treatment advances and prognosis for patients with adult T-cell leukemia-lymphoma. J Clin Exp Hematop. 2017;57(3):87-97.
Maeda T, Babazono A, Nishi T, Yasui M, Matsuda S, Fushimi k, et al. The Impact of Opportunistic Infections on Clinical Outcome and Healthcare Resource Uses for Adult T Cell Leukaemia. Plos One. 2015; 10(8): 2-12.
Dioverti M, Parikh S, Osmon D, Habermann T, Tande A. Cryptococcus neoformans infections in patients with lymphoproliferative neoplasms. Leuk Lymphoma. 2018,6:1-7.
Maeda T, Babazono A, Nishi T, Yasui M, Matsuda S, Fushimi K, et al. The Impact of Opportunistic Infections on Clinical Outcome and Healthcare Resource Uses for Adult T Cell Leukaemia. PLoS ONE. 2015;10(8): e0135042.
Chalkias S, Doweiko J, Eliopoulos G. An enabling act. Open Forum Infect Dis. 2014; 1(1): ofu008.
Marsh BJ. Infectious complications of human T cell leukemia/ lymphoma virus type I infection. Clin Infect Dis. 1996;23(1):138-45.
Tashiro T, Yamasaki T, Nagai H, Kikuchi H, Nasu M. Immunological studies on opportunistic infection and the development of adult T-cell leukemia. Intern Med 1992;31:1132-36.
Rhew DC, Gaultier CR, Daar ES, Zakowski PC, Said J. Infections in patients with chronic adult T-cell leukemia/lymphoma: Case report and review. Clin Infect Dis. 1995;21(4):1014-6.
Takasaki Y, Iwanaga M, Imaizumi Y, Tawara M, Joh T, Kohno T et al. Long-term study of indolent adult T-cell leukemia-lymphoma. Blood. 2010;115(22):4337-43.
Malpica L, Pimentel A, Reis I, Gotuzzo E, Lekakis L, Komanduri K. Epidemiology, clinical features, and outcome of HTLV-1-related ATLL in an area of prevalence in the United States. Blood Adv. 2018;2(6), 607-20.
Miyoshi I, Hatakeyama N, Daibata M, Taguchi H. Cutaneous and nodal cryptococcosis in an ATL Patient. Intern Med. 2006;45(19):1105-06.
Yamada W, Yamada H, Murata K, Kosugi H, Asano Y, Mochizuki K, Ishida K. Case of cryptococcal choroiditis in adult with T-cell leukemia/lymphoma. J Infect Chemother. 2018; S1341- 321X(18)30190-9.
Suzuki T, Ichiki Y, Kamihira T, Akamine M, Iida M, Ogawa K, Fujisawa K. A case of hepatic cryptococcosis complicated by adult T-cell leukemia. Nihon Shokakibyo Gakkai Zasshi. 112(12):2168-75.
Tanaka T, Sekioka T, Usui M, Imashuku S. Opportunistic Infections in Patients with HTLV-1 Infection. Case Rep Hematol. 2015:943867. .
Concha-Velasco F, González-Lagos E, Seas C, Bustamante B. Factors associated with early mycological clearance in HIV-associated cryptococcal meningitis. PLoS One. 2017;12(3): e0174459.
Henao-Martínez AF, Chastain DB, Franco-Paredes C. Treatment of cryptococcosis in non-HIV immunocompromised patients. Curr Opin Infect Dis. 2018;31(4):278-85.
Bongomin F, Oladele RO, Gago S, Moore CB, Richardson MD. A systematic review of fluconazole resistance in clinical isolates of Cryptococcus species. Mycoses. 2018;61(5):290-97.
NCCN Guidelines [Internet]. Clinical Practice Guideliness in Oncology.T cell-Lyphomas.Version.2019.[citado 1 de agosto de 2018]. Disponible en: https://www.nccn.org/professionals/physician_gls/pdf/t-cell.pdf
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