Hablando de pandemias y pared vascular. Desde el endotelio hacia lo socioeconómico-psicológico: una aproximación con evidencia

Autores/as

DOI:

https://doi.org/10.24265/horizmed.2021.v21n2.14

Palabras clave:

Pandemias, COVID-19, SARS-CoV-2, Endotelio

Resumen

En este artículo se hace una somera revisión de las pandemias sufridas por la humanidad a través de la historia y, además, un análisis de la presente pandemia, producida por un “extraño” virus que ha generado una enfermedad nueva y compleja. De ella, describimos su “nueva” fisiopatología centrada en la pared vascular (y, más concretamente, en el endotelio) y planteamos la posibilidad de detectar una disfunción endotelial subclínica en pacientes jóvenes, quienes han demostrado susceptibilidad y letalidad diferentes. Finalmente, se trata de contestar la pregunta: ¿esta pandemia nos cambiará o ayudará a cambiarnos?

Descargas

Los datos de descargas todavía no están disponibles.

Citas

Zhou P, Yang X-L, Wang X-G, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020; 579: 270-3.

Bogoch II, Watts A, Thomas-Bachli A, Huber C, Kraemer MUG, Khan K. Pneumonia of unknown aetiology in Wuhan, China: potential for international spread via commercial air travel. J Travel Med. 2020; 27(2): taaa008.

Lu H, Stratton CW, Tang YW. Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle. J Med Virol. 2020; 92(4): 401-2.

Cheng VCC, Lau SKP, Woo PCY, Yuen KY. Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection. Clin Microbiol Rev. 2007; 20(4): 660-94.

Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 2020; 109: 102433.

Wang W, Tang J, Wei F. Updated understanding of the outbreak of 2019 novel coronavirus (2019‐nCoV) in Wuhan, China. J Med Virol. 2020; 92(4): 441-7.

Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, et al. First case of 2019 Novel coronavirus in the United States. N Engl J Med. 2020; 382(10): 929-36.

Provenzano E. Coronavirus: Que sait-on du cas détecté à Bordeauz? [Internet]. Francia; 2020. Disponible en: https://www.20minutes.fr/bordeaux/2703783-20200126-coronavirus-sait-cas-detecte-bordeaux.

Folha de Sao Paulo. Brasil confirma primeiro caso do novo coronavírus [Internet]. Brasil; 2020. Disponible en: https://www1.folha.uol.com.br/equilibrioesaude/2020/02/brasil-confirma-primeiro-caso-do-novo-coronavirus.shtml.

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395(10223): 497-506.

Velavan TP, Meyer CG. The COVID‐19 epidemic. Trop Med Int Health. 2020; 25(3): 278-80.

Cui J, Li F, Shi ZL. Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol. 2019; 17(3): 181-92.

Monto AS. Medical Reviews. Coronaviruses. Yale J Biol Med. 1974; 47(4): 234-51.

Ole J. La Peste Negra, 1346-1353. La historia completa. Editorial Akal: Madrid; 2011.

López MM, Cardona Zorrilla AF. Rastros visibles del enemigo invisible: las epidemias en la historia. Rev Medicina. 2020; 42(2): 152-67.

Jácome Roca A. Las Pandemias de la Historia. Rev Medicina. 2020; 42(2): 140-2.

Diamond J. Guns, Germens y Steel. Penguim Random House Grupo Editorial: Madrid; 2007.

Carsana L, Sonzogni A, Nasr A, Rossi RS, Pellegrinelli A, Zerbi P, et al. Pulmonary post-mortem findings in a large series of COVID-19 cases from Northern Italy. MedRxiv. 2020.

Melgarejo E. COVID-19: extraño nuevo virus, endotelio y enseñanzas de una pandemia. Acta Méd Colomb. 2020; 45(3): 111-4.

Wong CK, Lam CWK, Wu AKL, Ip WK, Lee NLS, Chan IHS, et al. Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome. Clin Exp Immunol. 2004; 136(1): 95-103.

Klok FA, Kruip MJHA, van der Meer NJM, Arbous MS, Gommers DAMPJ, Kant KM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020; 191: 145-7.

Zhou F, Yu T, Du R, Fan G, Lui Y, Liu Z. Factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020; 395: 1054-62.

Loperena R, Van Beusecum JP, Itani HA, Engel N, Larougmanie F, Xiao L, et al. Hypertension and increased endothelial mechanical stretch promote monocyte differentiation and activation: roles of STAT3, interleukin 6 and hydrogen peroxide. Cardiovasc Res. 2018; 114(11): 1547-63.

Mitchell GF, Guo C-Y, Benjamin EJ, Larson MG, Keyes MJ, Vita JA, et al. Cross-sectional correlates of increased aortic stiffness in the community: the Framingham Heart Study. Circulation. 2007; 115(20): 2628-36.

Avogrp A, Albiero M, Mangazzo L. Diabetes Mellitus: an inflamatory state. Care. 2011; 34(Suppl. 2): S285-90.

Ellulu MS, Patimah I, Khaza'ai H, Rahmat A, Abed Y. Obesity and inflammation: the linking mechanism and the complications. Arch Med Sci. 2017; 13(4): 851-63.

Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020; 181(2): 271-80.

Zunke F, Rose-John S. The shedding protease ADAM17: Physiology and pathophysiology. Biochim Biophys Acta Mol Cell Res. 2017; 1864(11 Pt B): 2059-70.

Zheng Y-Y, Ma Y-T, Zhang J-Y, Xie X. COVID-19 and the cardiovascular system. Nat Rev Cardiol. 2020; 17(5): 259-60.

National Institutes of Health (NIH). Coronavirus disease 2019 (COVID-19) treatment Guidelines [Internet]. Bethesda; 2020. Disponible en: https://www.covid19treatmentguidelines.nih.gov/

Kreutz R, El-Hady Algharably EA, Azizi M, Dobrowolski P, Guzik T, Januszewicz A, et al. Hypertension, the renin–angiotensin system, and the risk of lower respiratory tract infections and lung injury: implications for COVID-19. Cardiovasc Res. 2020; 116(10): 1688-99.

Wu A, Good C, Downs JR, Fine MJ, Pugh MJ, Anzueto A, et al. The association of cardioprotective medications with pneumonia-related outcomes. 2014; 9(1): e85797.

Zhang P, Zhu L, Cai J, Lei F, Qin J-J, Xie J, et al. Association of inpatient use of angiotensin Converting Enzyme Inhibitors and Angiotensin II receptor blockers with mortality among patients with hypertension hospitalized with COVID-19. Circ Res. 2020; 126(12): 1671-81.

Levi M, Van der Poll T, Büller HR. Bidirectional relation between inflammation and coagulation. Circulation. 2004; 109(22): 2698-704.

Chatre C, Roubille F, Vernhet H, Jorgensen C, Pers Y-M. Cardiac complications attributed to chloroquine and hydroxychloroquine: a systematic review of the literature. Drug Saf. 2018; 41(10): 919-31.

Sala S, Peretto G, Gramegna M, Palmisano A, Villatore A, Vignale D, et al. Acute myocarditis presenting as a reverse TakoTsubo syndrome in a patient with SARS-CoV-2 respiratory infection. Eur Heart J. 2020; 41(19): 1861-2.

Ruan Q, Yang K, Wang W, Jiang L, Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 2020; 46(5): 846-8.

Chen D, Li X, Song Q, Hu C, Su F, Dai J, et al. Hypokalemia and clinical implications in patients with coronavirus disease 2019 (COVID-19). MeRxiv. 2020.

Marini JJ, Rocco PRM, Gattinoni L. Static and dynamic contributors to ventilator-induced lung injury in clinical practice. pressure, energy, and power. Am J Respir Crit Care Med. 2020; 201(7): 767-74.

Patel BK, Kress JP, Hall JB. Alternatives to invasive ventilation in the COVID-19 pandemic. JAMA. 2020; 324(1): 43-4.

World Health Organization. Corticosteroids for COVID-19: living guidance, 2 september 2020 [Internet]. Disponible en: https://apps.who.int/iris/handle/10665/334125

Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, Invernizzi P, et al. The ABO blood group locus and a chromosome 3 gene cluster associate with SARS-CoV-2 respiratory failure in an Italian-Spanish genome-wide association analysis. medRxiv. 2020.

Rippenger TJ, Uhrlaub JL, Watanabe M, Wong R, Castaneda Y, Pizzato HA, et al. Orthogonal SARS-CoV-2 serological assays enable surveillance of low prevalence communities and reveal durable humoral immunity. Immunity. 2020; 44-71.

##submission.downloads##

Publicado

2021-05-21

Cómo citar

1.
Melgarejo R E. Hablando de pandemias y pared vascular. Desde el endotelio hacia lo socioeconómico-psicológico: una aproximación con evidencia. Horiz Med [Internet]. 21 de mayo de 2021 [citado 25 de abril de 2024];21(2):e1521. Disponible en: https://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/1521

Número

Sección

Artículos de revisión