Correlation between eosinophils and aminotransferases among patients with and without diabetes from a polyclinic in the district of Villa El Salvador, Lima, Peru
DOI:
https://doi.org/10.24265/horizmed.2024.v24n4.07Keywords:
Blood Glucose , Eosinophils , Statistics, NonparametricAbstract
Objective: To determine the correlation between eosinophil count and aminotransferase levels among patients with and without diabetes from a polyclinic in the district of Villa El Salvador. Materials and methods: An observational, analytical and correlational study was conducted with 767 individuals, out of which 500 were patients without diabetes and 267 were patients diagnosed with diabetes mellitus for at least six months and undergoing treatment. The study variables included age, sex, basal glycemia, eosinophil count, aspartate aminotransferase (AST) levels and alanine aminotransferase (ALT) levels. The Kolmogorov-Smirnov test was used to assess normality and Spearman’s correlation coefficient was applied. The cut-off point for statistical significance was set at α = 0.05. Data analysis was performed using IBM Statistical Package for Social Sciences Statistics 25.0 software for Windows. Results: Among patients without diabetes, elevated AST and ALT levels were observed in 46.40 % and 27.20 %, respectively. In contrast, 62.50 % of patients with diabetes had elevated AST levels, while 35.50 % had elevated ALT levels. Among patients with diabetes, a moderate and negative correlation between eosinophil differential count and AST (Rho = -0.665) and ALT (Rho = -0.586) levels was found, whereas the group of patients without diabetes showed a weak or null correlation. Conclusions: Eosinophil count is moderately and negatively correlated with aminotransferase levels among patients with diabetes. Given the study limitations and the lack of direct precedents, further research with larger populations are needed. The interaction between polymorphonuclear cells, such as eosinophils, and hepatic and systemic inflammatory markers, such as aminotransferases, may serve as an early pathophysiological indicator of diabetes mellitus, potentially years or decades before the onset of micro- and macrovascular systemic complications of this endocrinopathy.
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References
Sampath Kumar A, Maiya AG, Shastry BA, Vaishali K, Ravishankar N, Hazari A, et al. Exercise and insulin resistance in type 2 diabetes mellitus: A systematic review and meta-analysis. Ann Phys Rehabil Med [Internet]. 2019;62(2):98-103.
Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract [Internet]. 2019;157:107843.
Aung WP, Htet AS, Bjertness E, Stigum H, Chongsuvivatwong V, Kjøllesdal MKR. Urban-rural differences in the prevalence of diabetes mellitus among 25-74 year-old adults of the Yangon Region, Myanmar: two cross-sectional studies. BMJ Open [Internet]. 2018;8(3):e020406.
Bantie GM, Wondaye AA, Arike EB, Melaku MT, Ejigu ST, Lule A, et al. Prevalence of undiagnosed diabetes mellitus and associated factors among adult residents of Bahir Dar city, northwest Ethiopia: a community-based cross-sectional study. BMJ Open [Internet]. 2019;9(10):e030158.
Goyal R, Singhal M, EEUU: StatPearls Jialal I. Type 2 Diabetes [Internet]. Publishing; 2021. https://www.ncbi.nlm.nih.gov/books/NBK513253/
De Candia P, Prattichizzo F, Garavelli S, De Rosa V, Galgani M, Di Rella F, et al. Type 2 diabetes: How much of an autoimmune disease? Front Endocrinol [Internet]. 2019;10:451.
Shetty SS, Kumari S. Fatty acids and their role in type-2 diabetes (Review). Exp Ther Med [Internet]. 2021;22(1):706.
Alzamil H. Elevated serum TNF-α is related to obesity in type 2 diabetes mellitus and is associated with glycemic control and insulin resistance. J Obes [Internet]. 2020;2020:5076858.
Fettrelet T, Gigon L, Karaulov A, Yousefi S, Simon H-U. The enigma of eosinophil degranulation. Int J Mol Sci [Internet]. 2021;22(13):7091.
Long H, Liao W, Wang L, Lu Q. A player and coordinator: The versatile roles of eosinophils in the immune system. Transfus Med Hemother [Internet]. 2016;43(2):96–108.
Yasuda K, Kuroda E. Role of eosinophils in protective immunity against secondary nematode infections. Immunol med [Internet]. 2019;42(4):148–55.
Gigon L, Yousefi S, Karaulov A, Simon H-U. Mechanisms of toxicity mediated by neutrophil and eosinophil granule proteins. Allergol Int [Internet]. 2021;70(1):30–8.
Jackson DJ, Akuthota P, Roufosse F. Eosinophils and eosinophilic immune dysfunction in health and disease. Eur Respir Rev [Internet]. 2022;31(163):210150.
Giuffrè M, Fouraki S, Comar M, Masutti F, Crocè LS. The importance of transaminases flare in liver elastography: Characterization of the probability of liver fibrosis overestimation by hepatitis C virus-induced cytolysis. Microorganisms [Internet]. 2020;8(3):348.
McGill MR. The past and present of serum aminotransferases and the future of liver injury biomarkers. EXCLI J [Internet]. 2016;15:817–28.
Rohani P, Imanzadeh F, Sayyari A, Kazemi Aghdam M, Shiari R. Persistent elevation of aspartate aminotransferase in a child after incomplete Kawasaki disease: a case report and literature review. BMC Pediatr [Internet]. 2020;20(1):73.
Tsalamandris S, Antonopoulos AS, Oikonomou E, Papamikroulis G-A, Vogiatzi G, Papaioannou S, et al. The role of inflammation in diabetes: Current concepts and future perspectives. Eur Cardiol [Internet]. 2019;14(1):50–9.
Miyake T, Matsuura B, Furukawa S, Yoshida O, Hirooka M, Kumagi T, et al. Nonalcoholic fatty liver disease is a risk factor for glucose intolerance onset in men regardless of alanine aminotransferase status. J Diabetes Investig [Internet]. 2021;12(10):1890–8.
González-Pérez B, Salas-Flores R, Echegollen-Guzmán, Pizarro-Chávez S, Guillén-Mata GA. Enzimas hepáticas elevadas, glucosa anormal de ayuno y diabetes no diagnosticada en medicina familiar. Rev Med Inst Mex Seguro Soc [Internet]. 2011;49(3):247–57.
Mirmiran P, Gaeini Z, Bahadoran Z, Azizi F. Elevated serum levels of aminotransferases in relation to unhealthy foods intake: Tehran lipid and glucose study. BMC Endocr Disord [Internet]. 2019;19(1):100.
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