Drug reaction with eosinophilia and systemic symptoms syndrome caused by extended-release carbamazepine: a case report
DOI:
https://doi.org/10.24265/horizmed.2021.v21n3.12Keywords:
Drug hypersensitivity syndrome, Carbamazepine, Exanthema , EosinophiliaAbstract
The drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but highly lethal drug hypersensitivity reaction. Thus, it requires an early diagnosis and timely management. We present the case of a 32-year-old female patient with a diagnosis of epilepsy and organic schizophreniform disorder, secondary to viral encephalitis, who was
treated with multiple drugs. Three weeks after the addition of extended-release carbamazepine to her usual therapy, the patient presented a diffuse welt-type skin rash, facial edema, fever, lymphadenopathy, leukocytosis with eosinophilia and elevated transaminases. Carbamazepine administration was discontinued, antihistamines and glucocorticoids were administered orally, and the patient showed a remarkable improvement.
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