Síndrome de reacción a fármacos con eosinofilia y síntomas sistémicos inducido por carbamazepina de liberación prolongada: reporte de un caso
DOI:
https://doi.org/10.24265/horizmed.2021.v21n3.12Palavras-chave:
Síndrome de hipersensibilidad a medicamentos, Carbamazepina, Exantema, EosinofiliaResumo
El síndrome de reacción a fármacos con eosinofilia y síntomas sistémicos es una reacción de hipersensibilidad a fármacos poco común, pero con una alta mortalidad, por ello se requiere un diagnóstico precoz y un manejo oportuno. Presentamos el caso de una mujer de 32 años con diagnóstico de epilepsia y trastorno esquizofreniforme orgánico, secundarios a encefalitis viral, y que ha recibido tratamiento con múltiples fármacos. Tres semanas después de añadir carbamazepina de liberación prolongada a su terapia habitual, la paciente presentó una erupción cutánea difusa tipo habón, edema facial, fiebre, linfadenopatía, leucocitosis con eosinofilia y elevación de las transaminasas. La administración de la carbamazepina fue suspendida, se administró antihistamínicos y glucocorticoides por vía oral, y la paciente mejoró.
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