Fahr’s syndrome in the elderly

Authors

DOI:

https://doi.org/10.24265/horizmed.2025.v25n3.16

Keywords:

Anciano; Enfermedad; Fahr; Síndrome

Abstract

Dear Editor: We have read the recent article published by Damián-Mucha et al. in this journal, which addresses the main features of Fahr's disease in an older adult (1). The diagnosis was incidental, based on non-contrast CT scan of the brain performed during the evaluation of an accidental fall, which revealed typical basal ganglia calcifications with lenticular predominance. Due to multiple comorbidities, the patient received multidisciplinary care during 41 days of hospitalization and subsequently remained under specialized home medical care for older adults (1). The authors emphasized the role of comprehensive clinical evaluation, laboratory and imaging tests, and geriatric counseling in providing quality care to these patients (1). In addition, they underscored the main features of Fahr's disease: progressive neurological dysfunction, basal ganglia calcifications, absence of endocrine or mitochondrial changes, toxins, or trauma, and no family history of autosomal dominant inheritance (1). Therefore, the following comments aim to highlight the importance of the referenced article.

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References

Damián-Mucha M, Takami-Angeles G, Arroyo-Zevallos C, Gamarra-Samaniego M, Torres-Salinas C. Enfermedad de Fahr en un adulto mayor, una visión

geriátrica. Horiz Med (Lima) [Internet]. 2025;25(1):e2855. Disponible en: https://doi.org/10.24265/horizmed.2025.v25n1.14

Fahr T. Idiopathische Verkalkung der Hirngefässe. In: Dictionnaire des maladies éponymiques et des observations princeps [Internet]. Paris:

Bibliothèque numérique Medic@; 1930–1931. p. 129–33. Disponible en: https://goo.su/lfsgy

Dos Santos VM, da Mata AMF, Ribeiro KRA, Calvo ICS. Fahr’s syndrome and secondary hypoparathyroidism. Rom J Intern Med [Internet]. 2016;54(1):63-5.

Disponible en: https://doi.org/10.1515/rjim-2016-0007

Snijders BMG, Peters MJL, van den Brink S, van Trijp MJCA, de Jong PA, Vissers LATM, et al. Infectious diseases and basal ganglia calcifications:

a cross-sectional study in patients with Fahr’s disease and systematic review. J Clin Med [Internet]. 2024;13(8):2365. Disponible en: https://doi.

org/10.3390/jcm13082365

Snijders BMG, Mathijssen G, Peters MJL, Emmelot-Vonk MH, de Jong PA, Bakker S, et al. The effects of etidronate on brain calcifications in Fahr’s

disease or syndrome: rationale and design of the randomised, placebo-controlled, double-blind CALCIFADE trial. Orphanet J Rare Dis [Internet].

;19(1):49. Disponible en: https://doi.org/10.1186/s13023-024-03039-7

Published

2025-09-11

How to Cite

1.
Modesto dos Santos V, Modesto Sugai K, Campos Nunes R. Fahr’s syndrome in the elderly. Horiz Med [Internet]. 2025Sep.11 [cited 2025Sep.14];25(3):e3329. Available from: https://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/3329

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Section

Letter to the editor

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