Reentry spontaneous pneumomediastinum at high altitude: a two-case report
DOI:
https://doi.org/10.24265/horizmed.2022.v22n2.12Keywords:
Mediastinal emphysema, Altitude, PeruAbstract
We describe two cases of spontaneous pneumomediastinum (SPM) that occurred in healthy, high-altitude native adolescent males when returning to their home from sea level. Both attended the Emergency Department of the Hospital Víctor Ramos Guardia in Huaraz, Ancash (3,052 m a.s.l.), in February 2020. Case 1 was a 16-year-old man who returned home (2,964 m a.s.l.) after twelve days at sea level (Lima). Six hours after returning, he went to work in the field. He then presented fatigue, cough, chest pain, dyspnea, and subcutaneous emphysema. Case 2 was a 17-year-old man who returned home (3,140 m a.s.l.) two weeks after staying at sea level (Barranca). Twelve hours after returning, he went to work in the field. He then presented cough, dyspnea, chest pain, sore throat, and subcutaneous emphysema. Both patients developed hypoxemia, and SPM was diagnosed with the help of chest X-rays. Case 2 was associated with mild high-altitude pulmonary edema. Both patients had no previous history of trauma, illicit drug use, comorbidity, and high-altitude-related diseases. Disease management was conservative, symptomatic, supportive, and based on clinical observation. When a healthy young patient comes to an emergency department because of chest pain, dyspnea, and subcutaneous emphysema, we should consider the possibility of SPM and immediately request frontal and lateral chest X-rays that include the cervical region. A differential diagnosis enables physicians to provide adequate and accurate treatment to patients with SPM.
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Cheng GS, Parghese TK, Park DR. Pneumomediastinum and mediastinitis. En: Murray & Nadel’s Textbook of Respiratory Diseases. 6th ed. Philadelphia: Elsevier Saunders; 2016. pp. 1496-503.
Murayama S, Gibo S. Spontaneous pneumomediastinum and Macklin effect: overview and appearance on computed tomography. World J Radiol. 2014; 6(11): 850-4.
Kouritas VK, Papagiannopoulos K, Lazaridis G, Baka S, Mpoukovinas I, Karavasilis V, et al. Pneumomediastinum. J Thorac Dis. 2015; 7(Suppl.1): S44-9.
Martín-Méndez HM, Montoya-Aguirre DE, Rodríguez-Perales MA, López-Chavira A, Kaneko-Wada T. Neumomediastino espontáneo manifestado por enfisema cervical, neumorraquia y neumoperitoneo: reporte de tres casos. AN ORL MEX. 2005; 50(2): 9-14.
Johnson NN, Toledo A, Endom EE. Pneumothorax, pneumomediastinum,and pulmonary embolism. Pediatr Clin North Am. 2010; 57(6): 1357-83.
Mohamed W, Exley C, Sutcliffe IM, Dwarakanath A. Spontaneous pneumomediastinum (Hamman's syndrome): presenting as acute severe asthma. J R Coll Physicians Edinb. 2019; 49(1): 31-3.
Londoño MP, Arenas LMA. Neumomediastino espontáneo: revisión del tema. Univ Med. 2017; 58(4).
Ferreira JIS, Alves MSF, Rebelo ARM, Lopes SMV, Ferreira CMG, Lopes AMTC. Spontaneous pneumomediastinum: when the rare also happens. Adolesc Saude. 2017; 14(4): 210-6.
Brand M, Bizos DB, Burnell L. A review of non-obstetric spontaneous pneumomediastinum and subcutaneous emphysema. S Afr J Surg. 2011; 49(3): 135-7.
Tsay C-Y, Chen Y-L, Chen C-S, Lin P-C, Wu M-Y. Pediatric spontaneous pneumomediastinum after a push-up exercise: an uncommon complication of a common exercise. Children (Basel). 2020; 7(12): 287.
Carvallo NA, Díaz RM. Neumomediastino espontáneo asociado a neumonía por COVID-19: reporte de dos casos. Rev Per Radiol. 2020; 20(1): 36-40.
Chen I-C, Tseng C-M, Hu J-H, Wu J-R, Dai Z-K. Spontaneous pneumomediastinum in adolescents and children. Kaohsiung J Med Sci. 2010; 26(2): 84-8.
Sahni S, Verma S, Grullon J, Esquire A, Patel P, Talwar A. Spontaneous pneumomediastinum: time for consensus. North Am J Med Sci. 2013; 5(9): 460-4.
Maeder MB, Brugger H, Pun M, Strapazzon G, Capello TD, Maggiorini M, et al. The STAR data reporting guidelines for clinical high altitude research. High Alt Med Biol. 2018; 19(1): 7-14.
Takada T, Matsumoto S, Hiramatsu T, Kojima E, Shizu M, Okachi S, et al. Spontaneous pneumomediastinum: an algorithm for diagnosis and management. Ther Adv Resp Dis. 2009; 3(6): 301-7.
Gil-Vargas M, González-Rodríguez LE, León-Aguilar VH. Neumomediastino secundario a efecto Macklin. Reporte de un caso. Acta Pediatr Méx. 2017; 38(5): 317-21.
Bilkis MD, Monteverde E. Efecto Macklin en el neumomediastino espontáneo pediátrico. Arch Argent Pediatr. 2010; 108(2): e33-6.
Acedo MJM, Serna NP, Herrero MN. Neumomediastino: otra causa de dolor torácico en la consulta. Med Gen Fam. 2014; 3(8): 240-2.
Bejvan SM, Godwin JD. Pneumomediastinum: old signs and new signs. Am J Roentgenol. 1996; 166(5): 1041-8.
Vosk A, Houston CS. Mediastinal emphysema in mountain climbers: report of two cases and review. Heart Lung. 1977; 6(5): 799-805.
Rosalén JF, Cantolla JD, Diego FIS. Neumomediastino espontáneo asintomático (NEA) en alpinista con signos de congelación y rabdomiolisis. Arch Bronconeumol. 1990; 26(5): 231-2.
Kalafat UM, Dogan S, Yazici R, Bulut B, Yaman D, Cander B. A rare cause of spontaneous pneumomediastinum: high altitude. Eurasian J Crit Care. 2019; 1(1): 29-31.
Campbell S, Vargas SA, Gómez JM, Escobar AE, Muñoz JK, Caquetá F. Síndrome de Hamman. Acta Med Colomb. 2016; 41 (3): 206-10.
Dionisio P, Martins L, Moreira S, Manique A, Macedo R, Caeiro F, et al. Spontaneous pneumomediastinum: experience in 18 patients during the last 12 years. J Bras Pneumol. 2017; 43(2): 101-5.
Zylak CM, Standen JR, Barnes GR, Zylak CJ. Pneumomediastinum revisited. Radiographics 2000; 20(4): 1043-57.
Espejo OJA, Orjuela APR. Neumomediastino espontáneo. Rev Colomb Radiol. 2014; 25 (3): 4026-30.
Martínez DS, González IB. Signo del diafragma continuo. Rev Argent Radiol. 2017; 81(4): 313-4.
Booms ZC, Barbee GA. Spontaneous pneumomediastinum in a pediatric patient after a 1600-m run: case report and literature review. J Am Osteopath Assoc. 2015; 115(5): 338-41.
Chan V, Raza A, Lashari BH, Patel R. Silent breathlessness: a case and brief review of spontaneous pneumomediastinum. Cureus. 2019; 11(4): e4487.
Kim KS, Jeon HW, Moon Y, Kim YD, Ahn MI, Park JK, et al. Clinical experience of spontaneous pnemomediastinum: diagnosis and treatmente. J Thorac Dis. 2015; 7(10): 1817-24.
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