Adherence to heme iron gummy supplementation among children 6 to 8 years of age in the district of Ate, Lima
DOI:
https://doi.org/10.24265/horizmed.2022.v22n4.05Keywords:
Anemia, Iron, Treatment Adherence and Compliance, ChildAbstract
Objective: To determine the adherence to heme iron gummy supplementation among children 6 to 8 years of age in the district of Ate, Lima. Materials and methods: A purposive non-probability sampling of 50 children 6 to 8 years of age, of both sexes, registered in the municipality of Ate. The study included children with no anemia, mild anemia and moderate anemia. The hemoglobin level was determined at the beginning and end of the intervention. Each child ingested a heme iron gummy (9 mg elemental iron) for four months. Results: Adherence to heme iron gummies consumption was 100 %; none of the children reported side effects and all of them liked the taste of the gummies. Children with moderate anemia, mild anemia and no anemia had a hemoglobin concentration of 10.48 ± 0.48 g/dL and 11.43 ± 0.38 g/dL, 11.21 ± 0.14 g/dL and 12.17 ± 0.51 g/dL, and 11.68 ± 0.13 g/dL and 12.57 ± 0.53 g/dL at the beginning and end of the intervention, respectively. The p value in all groups was statistically significant (p = 0.000). Out of the children with mild anemia, 94.74 % achieved normal hemoglobin levels. Conclusions: All age groups had good adherence to heme iron gummies consumption and increased their hemoglobin levels.
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References
Organización Mundial de la Salud. Concentraciones de hemoglobina para diagnosticar la anemia y evaluar su gravedad [Internet]. OMS; 2011. Disponible en: https://apps.who.int/iris/handle/10665/85842
Stevens GA, Finucane MM, De-Regil LM, Paciorek CJ, Flaxman SR, Branca F, et al. Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995-2011: A systematic analysis of population-representative data. Lancet Global Health. 2013; 1(1): e16-25.
Halterman JS, Kaczorowski JM, Aligne CA, Auinger P, Szilagyi PG. Iron deficiency and cognitive achievement among school aged children and adolescents in the United States. Pediatrics. 2001; 107(6): 1381-6.
Hurtado EK, Claussen AH, Scott KG. Early childhood anemia and mild or moderate mental retardation. Am J Clin Nutr. 1999; 69(1): 115-9.
Rivera FA, Walter TK. Effects of iron deficiency anemia in infancy on later school performance. J Pediatr. 1997; 73(Supl. 1): S49-54.
Ekiz C, Agaoglu L, Karakas Z, Gurel N, Yalcin I. The effect of iron deficiency anemia on the function of the immune system. Hematol J. 2005; 5(7): 579-83.
Duque X, Flores-Hernández S, Flores-Huerta S, Méndez-Ramírez I, Muñoz S, Turnbull B, et al. Prevalence of anemia and deficiency of iron, folic acid, and zinc in children younger than 2 years of age who use the health services provided by the Mexican Social Security Institute. BMC Public Health. 2007; 7: 345-62.
Machado K, Alcarraz G, Morinico E, Briozzo T, Gutiérrez S. Anemia ferropénica en menores de un año usuarios de CASMU-IAMPP: prevalencia y factores asociados. Arch Pediatr Urug. 2017; 88(5): 254-60.
Cordero D, Aguilar AM, Casanovas C, Vargas E, Lutter CK. Anemia in Bolivian children: a comparative analysis among three regions of different altitudes. Ann N Y Acad Sci. 2019; 1450(1): 281-90.
Durán P, Mangialavoria G, Biglieria A, Kogana L, Gilardon EA. Estudio descriptivo de la situación nutricional en niños de 6-72 meses de la República Argentina. Resultados de la Encuesta Nacional de Nutrición y Salud (ENNyS). Arch Argent Pediatr. 2009; 107(5): 397-404.
Brito A, Hertrampf E, Olivares M. Low prevalence of anemia in children aged 19 to 72 months in Chile. Food Nutr Bull. 2012; 33(4): 308-11.
Ayoya MA, Ngnie-Teta I, Séraphin MN, Mamadoultaibou A, Boldon E, Saint-Fleur JE. Prevalence and Risk Factors of Anemia among Children 6–59 Months Old in Haiti. Anemia. 2013; 2013: 502968.
Ministerio de Salud. Plan Nacional de Reducción y Control de la Anemia y la Desnutrición Crónica Infantil 2017-2021 [Internet]. Lima: Minsa; 2017. Disponible en: http://bvs.minsa.gob.pe/local/MINSA/4189.pdf
Sharp PA. Intestinal iron absorption: regulation by dietary & systemic factors. Int J Vitam Nutr Res. 2010; 80(4-5): 231-42.
Yasa B, Agaoglu L, Unuvar E. Efficacy, Tolerability, and Acceptability of Iron Hydroxide Polymaltose Complex versus Ferrous Sulfate: A Randomized Trial in Pediatric Patients with Iron Deficiency Anemia. Int J Pediatr. 2011; 2011: 524520.
Ministerio de Salud. Informe técnico: Vigilancia centinela de adherencia a sales de hierro en niños de 6 a 35 meses y gestantes atendidos en Establecimientos de salud del Ministerio de Salud en 12 departamentos del Perú. DEVAN. Mayo 2015. Lima: Minsa; 2015.
Powers JM, Buchanan GR, Adix L, Zhang S, Gao A, Timothy L, et al. Effect of Low-Dose Ferrous Sulfate vs Iron Polysaccharide Complex on Hemoglobin Concentration in Young Children With Nutritional Iron-Deficiency Anemia. A Randomized Clinical Trial. JAMA. 2017; 317(22): 2297-304.
Aycicek A. Ferrous Sulfate Versus Ferrous Fumarate Plus Zinc Sulfate and Vitamin C for Treatment of Iron Deficiency Anemia in Children. Glob J Hematol Blood Transfus. 2015; 2: 15-9.
Whitney R, Centrone WA, Mamani HS, Falkenstein K, Levine RS, Harris J, et al. Impact of a collaborative childhood anaemia intervention programme in Peru. Trop Med Int Health. 2021; 26(6): 680-6.
Wezgier LP, Kubiak M, Liebert A, Clavel T, Montagne A, Stennevin A, et al. Ferrous sulfate oral solution in young children with iron deficiency anemia: An open-label trial of efficacy, safety, and acceptability. Pediatr Int. 2020; 62(7): 820-7.
Huamán-Espino L, Aparco JP, Nuñez-Robles E, Gonzáles E, Pillaca J, Mayta-Tristán P. Consumo de suplementos con multimicronutrientes chispitas® y anemia en niños de 6 a 35 meses: estudio transversal en el contexto de una intervención poblacional en Apurímac, Perú. Rev Peru Med Exp Salud Pública. 2012; 29(3): 314-23.
Mc Lennan JD, MacGregor S. Anemia Screening and Treatment Outcomes of Children in a Low-resource Community in the Dominican Republic. J Trop Pediatr. 2016; 62(2): 116-22.
Faqih AM, Kakish SB, Izzat M. Effectiveness of intermittent iron treatment of two- to six-year-old Jordanian children with iron-deficiency anemia. Food Nutr. Bull. 2006; 27(3): 220-7.
Guija-Guerra H, Guija-Poma E, Pardo-Ponce J, Inocente-Camones M, Camarena-Chaviguri L. Generación de radicales libres por el efecto de vitamina C sobre un jarabe antianémico de sulfato ferroso. Horiz Méd. 2018; 18(4): 35-41.
Timoshnikov VA, Kobzeva TV, Polyakov NE, Kontoghiorghes GJ. Redox Interactions of Vitamin C and Iron: Inhibition of the Pro-Oxidant Activity by Deferiprone. Int J Mol Sci. 2020; 21(11): 3967.
Shen J, Griffiths PT, Campbell JS, Utinger B, Kalberer M, Paulson SE. Ascorbate oxidation by iron, copper and reactive oxygen species: review, model development, and derivation of key rate constants. Sci Rep. 2021; 11: 7417.
Roughead ZK, Zito CA, Hunt JR. Initial uptake and absorption of nonheme iron and absorption of heme iron in humans are unaffected by the addition of calcium as cheese to a meal with high iron bioavailability. Am J Clin Nutr. 2002; 76(2): 419-25.
Dasa F, Abera T. Factors affecting iron absorption and mitigation mechanisms: a review. Int J Agric Sc Food Technol. 2018; 4(1): 24-30.
McLennan JD, Steele M. Anemia Screening and Treatment Outcomes of Children in a Low-resource Community in the Dominican Republic. J Trop Pediatr. 2016; 62(2): 116-22.
Ba DM, Ssentongo P, Kjerulff KH, Na M, Liu G, Gao X, et al. Adherence to Iron Supplementation in 22 Sub-Saharan African Countries and Associated Factors among Pregnant Women: A Large Population-Based Study. Curr Dev Nutr. 2019; 3(12): 120.
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