Neurodevelopmental sequelae in premature newborns with extremely low weight and with very low weight at two years of age who left the Neonatal Intensive Care Unit of the Hospital Nacional Edgardo Rebagliati Martins 2009-2014
DOI:
https://doi.org/10.24265/horizmed.2017.v17n2.02Keywords:
Neurodevelopment, Premature, NewbornAbstract
Objective: The purpose of this study is to describe the neurodevelopmental sequelae in premature newborns with extremely low weight and with very low weight at two years of age who left the Neonatal Intensive Care Unit of the Hospital Nacional Edgardo Rebagliati Martins.
Materials and methods: A descriptive, retrospective, cross-sectional study in a population of 190 premature newborns with extremely low weight and with very low weight born from January 2009 to June 2014 who left the Neonatal Intensive Care Unit and took part in the follow-up program. The psychomotor development, sensorineural hearing loss, retinopathy of prematurity, presence of cerebral palsy and convulsive syndrome were assessed.
Results: The average weight at birth was 1,180.53 ± 212.40 grams with a gestational age of 29.86 ± 2.33 weeks, and 51.58% of the newborns were male. Forty-two point six three percent (42.63%) of the premature newborns with very low weight showed retardation of psychomotor development; 25.26%, retinopathy; 13.68%, sensorineural hearing loss; 3.68%, cerebral palsy; and 3.68%, convulsive syndrome. Fifty-two point two seven percent (52.27%) of the premature newborns with extremely low weight showed retardation of psychomotor development; 50%, retinopathy; 15.91%, sensorineural hearing loss; and 2.27%, convulsive syndrome.
Conclusions: Retardation of psychomotor development and retinopathy were the most important complications shown by premature newborns with extremely low weight and with very low weight at two years of age.
Downloads
References
March of Dimes, PMNCH, Save the Children, WHO. Born too soon: The Global Action Report on Preterm Birth. Howson CP, Kinney MV, Lawn JE, eds. Ginebra: World Health Organization, 2012.
Blencowe H, Cousens S, Oestergaard MZ, Chou D, Moller AB, Narwal R, et al. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet. 2012; 379 (9832):2162-72.
Liu L, Oza S, Hogan D, Perin J, Rudan I, Lawn J, et al. Global, regional, and national causes of child mortality in 2000-13, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet. 2015; 385 (9966):430-40.
Lawn J, Davidge R, Paul V, von Xylander S, de Graft Johnson J, Costello A, et al. Born too soon: care for the preterm baby. Reprod Health. 2013; 10(1):S5.
Mathews T, MacDorman M. Infant mortality statistics from the 2010 period linked birth/infant death data set. Natl Vital Stat Rep. 2013; 62(8):1-26.
Barros F, Barros A, Villar J, Matijasevich A, Domingues M, Victora C. How many low birthweight babies in low- and middle-income countries are preterm?. Rev Saude Pública. 2011; 45 (3):607-16.
Vohr B. Neurodevelopmental outcomes of extremely preterm infants. Clin Perinatol.2014; 41 (1):241-55.
Volpe J, Kinney H, Jensen F. The developing oligodendrocyte: key cellular target in brain injury in the premature infant. Int J Dev Neurosci. 2011; 29 (4):423-40.
Rand K, Austin N, Inder T, Bora S, Woodward L. Neonatal infection and later neurodevelopmental risk in the very preterm infant. J Pediatr.2016; 170:97-104.
O’Shea T, Joseph R, Kuban K, Allred E, Ware J, Coster T, et al. Elevated blood levels of inflammation-related proteins are associated with an attention problem at age 24 mo in extremely preterm infants. Pediatr Res. 2014; 75 (6):781-7.
Brunkhorst J, Weiner J, Lantos J. Infants of borderline viability: the ethics of delivery room care. Semin Fetal Neonatal Med. 2014; 19 (5):290-5.
Schmidt B, Anderson PJ, Doyle LW, Dewey D, Grunau RE, Asztalos EV, et al. Survival without disability to age 5 years after neonatal caffeine therapy for apnea of prematurity. JAMA. 2012; 307 (3):275-82.
Kawaza K, Machen H, Brown J, Mwanza Z, Iniguez S, Gest A, et al. Efficacy of a low-cost bubble CPAP system in treatment of respiratory distress in a neonatal ward in Malawi. PLoS One. 2014; 9 (1):1-8.
Arreola-Ramírez G, Fernández-Carrocera LA, Ramírez-López CZ, Barrera-Reyes RH, Regil-Vélez LM, Ríos-Flores B, et al. Desarrollo neurológico en el primer año de vida de infantes prematuros con peso menor a 1,500 g en una institución de tercer nivel. Perinatol Reprod Hum. 2011; 25 (3):146-54.
Barra L, Alvarado R. Frecuencia de riesgo neurobiológico en recién nacidos. Rev Chil Pediatr. 2012; 83(6):552-62.
Wang Y, Tanbo T, Ellingsen L, Abyholm T, Henriksen T. Effect of pregestational maternal, obstetric and perinatal factors on neonatal outcome in extreme prematurity. Arch Gynecol Obstet. 2011; 284 (6):1381-7.
García-Muñoz F, García-Alix A, García J, Figueras J. Morbidity and mortality in newborns at the limit of viability in Spain: a population-based study. An Pediatr (Barc). 2014; 80 (6):348- 56.
Port A, Chan R, Ostmo S, Choi D, Chiang M. Risk factors for retinopathy of prematurity: insights from outlier infants. Graefes Arch Clin Exp Ophthalmol. 2014; 252 (10): 1669-77.
Yau G, Lee J, Tam V, Yip S, Cheng E, Liu C, et al. Incidence and risk factors for retinopathy of prematurity in multiple gestations: a chinese population study. Medicine (Baltimore). 2015; 94 (18):e867.
Fernández R, D’Apremont I, Domínguez A., Tapia J, Red Neonatal Neocosur. Supervivencia y morbilidad en recién nacidos de muy bajo peso al nacer en una Red Neonatal sudamericana. Arch Argent Pedriatr. 2014; 112 (5):405-12.
Beligere N, Perumalswamy V, Tandon M, Mittal A, Floora J, Vijayakumar B, et al. Retinopathy of prematurity and neurodevelopmental disabilities in premature infants. Semin Fetal Neonatal Med. 2015; 20 (5):346-53.
Medina M, Kahn I, Muñoz P, Leyva J, Moreno J, Vega S. Neurodesarrollo infantil: características normales y signos de alarma en el niño menor de cinco años. Rev Peru Med Exp Salud Pública. 2015; 32 (3):565-73.
García P, San Feliciano L, Benito F, García R, Guzmán J, Salas S, et al. Evolución a los 2 años de edad corregida de una cohorte de recién nacidos con peso inferior o igual a 1.500 g de los hospitales pertenecientes a la red neonatal SEN1500. An Pediatr. 2013; 79 (5):279-87.
Moore T, Hennessy E, Myles J, Johnson S, Draper E, Costeloe K, et al. Neurological and developmental outcome in extremely preterm children born in England in 1995 and 2006: the EPICure studies. BMJ. 2012; 345:e7961.
Peñaloza-López Y, García-Pedroza F, Castillo-Maya G, JiménezPérez J. Hipoacusia-sordera congénita y su relación con el peso bajo al nacimiento en México y en algunos otros países. Rev Mex AMCAOF. 2012; 1 (2):82-9.
Borkoski S, Falcón J, Bueno J, Pérez J, López Z, Ramos Á. Resultados de un programa de detección precoz de la hipoacusia neonatal. Acta Otorrinolaringológica Española. 2013; 64(2):92-6.
Bielecki I, Horbulewicz A, Wolan T. Risk factor associated with hearing loss in infants: an analysis of 5282 referred neonates. Int J Pediatr Otorhinolaryngol. 2011;75(7):925-30.
Nuñez-Batalla F, Trinidad-Ramos G, Sequí-Canet J, Alzina de Aguilar V, Jáudenes-Casaubón C. Indicadores de riesgo de hipoacusia neurosensorial infantil. Acta Otorrinolaringologica Española. 2012;63(5): 382-90.
Hirvonen M, Ojala R, Korhonen P, Haataja P, Eriksson K, Gissler M, et al. Cerebral palsy among children born moderately and late preterm. Pediatrics. 2014;134(6):1584-93.
Himmelmann K, Uvebrant P. The panorama of cerebral palsy in Sweden. XI. Changing patterns in the birth-year period 2003-2006. Acta Paediatr. 2014; 103(6):618-24.
da Silva A, Tavares L, da Silva J, Ribeiro L. Factors related to motor developmental delay of newborns. Journal of Human Growthand Development. 2014; 24 (3):320-7.
Suppiej A, Franzoi M, Vedovato S, Marucco A, Chiarelli S, Zanardo V. Neurodevelopmental outcome in preterm histological chorioamnionitis. Early Hum Dev. 2009; 85 (3):187-9.
Taboada-Lugo N, Quintero-Escobar K, Casamajor-Castillo M,González-Torres K, Marrero-Infante J, Cruz-Ubeda S, et al. Epidemiología de la parálisis cerebral en el Estado Plurinacional de Bolivia, 2009-2012. Rev Peru de Epidemiol. 2013; 17 (2):1-7.
Schlapbach L, Adams M, Proietti E, Aebischer M, Grunt S, Borradori-Tolsa C, et al. Outcome at two years of age in a Swiss national cohort of extremely preterm infants born between 2000 and 2008. BMC Pediatr. 2012; 12: 198.
Published
How to Cite
Issue
Section
License
Copyright (c) 2017 Horizonte Médico (Lima)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Horizonte Médico (Lima) (Horiz. Med.) journal’s research outputs are published free of charge and are freely available to download under the open access model, aimed at disseminating works and experiences developed in biomedical and public health areas, both nationally and internationally, and promoting research in the different fields of human medicine. All manuscripts accepted and published in the journal are distributed free of charge under the terms of a Creative Commons license – Attribution 4.0 International (CC BY 4.0).
